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Our lab develops advanced optical microscopy techniques to investigate biological phenomena at the nanoscale. By combining cutting-edge optical measurements and interdisciplinary biological approaches, we directly observe the dynamics of tiny structures within living cells under the microscope. Our primary goal is to uncover the regulatory mechanisms behind these seemingly random movements at the nanoscopic scale and understand how they intricately give rise to life processes.

To achieve this, we are developing innovative optical microscope techniques. In particular, we are pioneering imaging technologies that measure linear scattering as a signal through light interference. We can capture fleeting dynamic behaviors at very high speeds—hundreds of thousands of frames per second. The ultrahigh detection sensitivity and spatiotemporal resolution of our technology offer unique opportunities to investigate the nanoscopic movements of single virus particles and single lipid molecules on the cell plasma membrane. Moreover, using correlation spectroscopy analysis for dynamic light scattering signals, we unravel chromatin organization and dynamics in live cell nuclei in a label-free manner.

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