Our lab builds label-free optical microscopes that reveal how living cells move, fluctuate, and organize in real time. By combining interferometric scattering, quantitative imaging, and biophysical modeling, we probe molecular dynamics at nanometer and microsecond scales without relying on fluorescent labels. We use these tools to uncover the physical principles underlying chromatin organization, gene regulation, and disease-associated cellular states.

2026-03-01    ▏[Open Position🔬] Postdoc/Research Assistant (Bioimaging and Biophysics)

2026-01-16     ▏Congratulations to Yi-Jhen, Yan-Hsien, and Hsiang-Yu!

2026-01-02    ▏Our work on AI-assisted label-free 3D chromatin optical imaging is published

2025-12-05    ▏Our work on transmission-based mass photometry is published

2025-05-07   ▏Hsiang-Yu wins Best Poster Award

2025-02-26   ▏Our work on the simple implementation of iSCAT using low-coherence light is published

2024-09-01   ▏Josephine Liang wins the 2024 IAMS Summer Internship Award

2024-07-23   ▏Dr. Hsieh wins the Young Investigator Award

2024-06-11     ▏Chih-Chen wins CTCI Outstanding Physics Undergraduate Award

2024 -01-31    ▏Chih-Chen wins the Best Poster Award at TPS 2024