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ABOUT
ABOUT
Our lab develops ultrasensitive optical microscopy and quantitative measurement methods to investigate nanoscale dynamics in living systems. By combining interferometric scattering, high-speed imaging, and biophysical analysis, we probe rapid molecular motions and structural fluctuations that are difficult to resolve with conventional microscopy. Our goal is to understand how nanoscale dynamics contribute to cellular organization and function, particularly in chromatin organization, gene regulation, and disease-associated cellular states.
SELECTED SCIENTIFIC ADVANCES
SELECTED SCIENTIFIC ADVANCES
Probing nucleus dynamics in living cells
Label-free interferometric imaging enables quantitative studies of chromatin organization and dynamics in live cell nuclei.
ACS Nano (2022); Comm. Bio. (2024); Biomed. Opt. Exp. (2026).
Quantitative 3D single-particle measurements
Spiral-phase interferometric microscopy enables robust 3D particle tracking and characterization.
Label-free detection of single proteins
Coherent brightfield microscopy reaches the sensitivity required to detect individual unlabeled proteins.
NEWS
NEWS
2026-10-15 ▏[Open Position🔬] Postdoc/Research Assistant (Bioimaging and Biophysics)
2026-01-16 ▏Congratulations to Yi-Jhen, Yan-Hsien, and Hsiang-Yu!
2026-01-02 ▏Our work on AI-assisted label-free 3D chromatin optical imaging is published
2025-12-05 ▏Our work on transmission-based mass photometry is published
2025-05-07 ▏Hsiang-Yu wins Best Poster Award
2025-02-26 ▏Our work on the simple implementation of iSCAT using low-coherence light is published
2024-09-01 ▏Josephine Liang wins the 2024 IAMS Summer Internship Award
2024-07-23 ▏Dr. Hsieh wins the Young Investigator Award
2024-06-11 ▏Chih-Chen wins CTCI Outstanding Physics Undergraduate Award
2024 -01-31 ▏Chih-Chen wins the Best Poster Award at TPS 2024
RESEARCH
RESEARCH
Probing nanoscale organization and dynamics in living cell nuclei to investigate their physical properties and relationships with genome regulation and cellular function.
Developing ultrasensitive optical measurements for high-speed, label-free imaging and quantitative characterization of nanoparticles and biomolecules.
Revealing nanoscale membrane organization and molecular heterogeneity through high-speed single-particle tracking and quantitative motion analysis.
Investigating the rapid motion and transient interactions of individual viruses at cell surfaces during the earliest stages of infection.
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